Mechanisms of potentiation of the mammalian GABA_Areceptor by the marine cembranoid eupalmerin acetate

Abstract

We conclude that EPA either interacts with the putative neurosteroid binding site on the GABA(A) receptor or shares with neurosteroids the key transduction elements involved in channel potentiation by steroids. The results indicate that cembranoids represent a novel class of GABA(A) receptor modulators.