Fluid shear stress‐induced nitric oxide production in human cavernosal endothelial cells: inhibition by hyperglycaemia

Abstract

These in vitro data suggest that FSS contributes to eNOS activation and NO release in HCCECs, and supports in vivo reports suggesting a role for haemodynamic signalling in the erectile response. Treatment with high glucose levels prevented FSS-induced NO release, suggesting a mechanism that may contribute to decreased erectile function associated with diabetes.