COPPER(I)-PROMOTED COUPLING REACTION OF ARYL HALIDES WITH SODIUM DIETHYLMALONATE

Abstract

Abstract Copper(I)-promoted coupling reaction of aryl halides with sodium diethylmalonate occurred smoothly in dioxane. The qualitative trends in the activity of copper(I) salt followed the order: CuBr > CuI > CuBF4(CH3CN)4 > CuCl. The activity was lowered in the presence of coordinating molecule such as acetonitrile, pyridine, NaI, phosphine, and sulfide. The reaction was generally applicable to aryl halides with various substituents.