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The Sensitivity of Smooth and Rough Gram-Negative Bacteria to the Immune Bactericidal Reaction
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1970
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Pathogenic MicrobiologyMicrobial PathogensBacteriologyImmunologyBacterial PathogensMedical MicrobiologyCell SurfaceInfection ControlAntimicrobial ResistanceAerobic CulturingHealth SciencesVirulence FactorRough StrainsImmune Bactericidal ReactionClinical MicrobiologyNormal AntibodyGram-negative BacteriologyAntimicrobial SusceptibilityRough Gram-negative BacteriaAntibioticsMicrobiologyMedicineDiagnostic Microbiology
Rough strains of gram-negative bacteria are not necessarily more sensitive than smooth strains to the bactericidal action of normal serum or C. The resistance of certain smooth strains to C may merely reflect a lack of normal antibody in serum. Other smooth organisms may be refractory to C even when sensitized with homologous antiserum. In such instances, it is believed that the C-sensitive substance may be too far removed or inaccessible to the C enzymes activated by antigen–antibody complexes on the cell surface (6).