A CD 4: immunoglobulin fusion protein with antiviral effects against HIV

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

Angus Dalgleish, Peter C. L. Beverley, Paul R. Clapham et al. · Nature · 1984 · 3.5K citations · Full text

Human Retrovirus, Immunology, Antiviral Response +8

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

David Klatzmann, Éric Champagne, S. Chamaret et al. · Nature · 1984 · 2.4K citations

Viral Persistence, Human Retrovirus, Immunology +9

Binding of HTLV-III/LAV to T4 ⁺ T Cells by a Complex of the 110K Viral Protein and the T4 Molecule

J. Steven McDougal, Melanie S. Kennedy, Julie M. Sligh et al. · Science · 1986 · 988 citations

Viral Replication, Viral Protein, Viral Polymerase Mechanism +19

Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor

Laurence A. Lasky, Gerald Nakamura, Douglas H. Smith et al. · Cell · 1987 · 823 citations

Cd4 Receptor, Human Retrovirus, G Protein-coupled Receptor +10

Interaction between CD4 and class II MHC molecules mediates cell adhesion

Carolyn A. Doyle, Jack L. Strominger · Nature · 1987 · 819 citations

Class Ii Mhc, Cell Adhesion, Immunology +9