Carbenicillin and Hypokalemia

Abstract

Letters1 May 1973Carbenicillin and HypokalemiaJEAN KLASTERSKY, M.D., BAUDOUIN VANDERKELEN, M.D., DIDIER DANEAU, MONIGUE MATHIEU, M.D.JEAN KLASTERSKY, M.D.Search for more papers by this author, BAUDOUIN VANDERKELEN, M.D.Search for more papers by this author, DIDIER DANEAUSearch for more papers by this author, MONIGUE MATHIEU, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-774 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Brunner and Frick (1) drew attention to the development of hypokalemia and metabolic alkalosis with high-dose sodium benzylpenicillin therapy; and electrolyte disturbances have been recorded occasionally in patients receiving carbenicillin (2).During the last 2 years 90 patients were treated with carbenicillin (30 g daily) in our hospital; 25 received carbenicillin alone; 29 were treated with carbenicillin and gentamicin and 36 with carbenicillin and cephalothin. In 16 (18%) patients abnormally low levels of serum potassium were observed during therapy with carbenicillin. In 8 of these 16 patients hypokalemia was reported only once during antibiotic therapy; moreover, in...References1. BRUNNER F and FRICK P: Hypokalemia, metabolic alkalosis, and hypernatraemia due to "massive" sodium penicillin therapy. Br Med J 4:550-552, 1968 CrossrefMedlineGoogle Scholar2. HOFFBRAND B and STEWART J: Carbenicillin and hypokalemia. Br Med J 4:746, 1970 CrossrefMedlineGoogle Scholar3. BODEY G, RODRIGUEZ V, and LUCE J: Carbenicillin therapy of Gram-negative bacilli infections. Am J Med Sci 257:408-414, 1969 CrossrefMedlineGoogle Scholar4. MARKS M and EICKHOFF T: Carbenicillin: a clinical and laboratory evaluation. Ann Intern Med 73:179-187, 1970 LinkGoogle Scholar5. TATTERSALL M, BATTERSBY G, and SPIERS A: Antibiotics and hypokalæmia (letter). Lancet 1:630-631, 1972 MedlineGoogle Scholar This content is PDF only. 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Author, Article, and Disclosure InformationAuthors: JEAN KLASTERSKY, M.D.; BAUDOUIN VANDERKELEN, M.D.; DIDIER DANEAU; MONIGUE MATHIEU, M.D.Affiliations: Institut Jules Bordet Centre des Tumeurs de l'Université Libre de Bruxelles Brussels Belgium PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPotassium and the DyskalemiasNutrition in the Age of PolypharmacyMetabolic Alkalosis, Bedside and BenchInfluence of Medication on Nutritional StatusDisorders of Potassium MetabolismFever and neutropenia during intensive chemotherapySpurious rise in total carbon dioxide and chloride with negative anion gap after cystogramFever and neutropenia during intensive chemotherapyPotassium and anaesthesiaCPharmacological Considerations for Renal Failure and DialysisSevere hypokalaemiaDisorders of Potassium Homeostasis in Critically Ill PatientsDisorders associated with an altered anion gapDisorders of Potassium MetabolismGastrointestinal Disorders Caused by Medication and Electrolyte Solution Osmolality during Enteral NutritionDrug-Induced Electrolyte DisordersPharmacological Aspects of Renal Failure and DialysisPiperacillin Sodium: Antibacterial Spectrum, Pharmacokinetics, Clinical Efficacy, and Adverse ReactionsCarbenicillin and TicarcillinPiperacillin or ticarcillin plus amikacinLysozyme and hypokalaemiaPiperacillin therapy for serious bacterial infectionsDrug Therapy in Renal Failure: Dosing Guidelines for Adults Part I: Antimicrobial Agents, AnalgesicsWILLIAM M. 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COGGINS, M.D.THE MANAGEMENT OF FEBRILE EPISODES IN • NEUTROPENIC CANCER PATIENTSThe Nephrotoxicity of Antimicrobial AgentsPirbenicillin: Comparison with Carbenicillin and BL-P1654, Alone and with Gentamicin, Against Pseudomonas aeruginosaGastrointestinale Komplikationen akuter LeukämienComparative In Vitro Activity of Pirbenicillin, Ticarcillin, and Carbenicillin Against Pseudomonas aeruginosaLa TicarcillineClinical and Pharmacological Studies of Ticarcillin in Gram-Negative InfectionsMeasurement of Urinary Electrolytes — Indications and LimitationsHypokalemia in LeukemiaJOEL S. GREENBERGER, M.D., DAVID S. ROSENTHAL, M.D., WILLIAM C. MOLONEY, M.D.BL-P1654, Ticarcillin, and Carbenicillin: In Vitro Comparison Alone and in Combination with Gentamicin Against Pseudomonas aeruginosaHypokalaemia in Acute Myeloid LeukaemiaM. A. MIR, M.B., M.R.C.P., B. BRABIN, M.B., Ch.B., O. T. TANG, M.B., M.R.C.P., M. J. LEYLAND, M.R.C.P., I. W. DELAMORE, Ph.D., F.R.C.P.E.Calcium and potassium disturbances in acute leukemiaCephalothin, carbenicillin, and gentamicin combination therapy for febrile patients with acute non-lymphocytic leukemiaTicarcillin, a New Semisynthetic Penicillin Active on Pseudomonas Aeruginosa: In Vitro Activity and Blood Levels in Man 1 May 1973Volume 78, Issue 5Page: 774-775KeywordsAntibioticsElectrode recordingPotassiumSodium ePublished: 1 December 2008 Issue Published: 1 May 1973 PDF downloadLoading ...