A novel family of genes encoding putative pheromone receptors in mammals

TLDR

In mammals, olfactory perception is mediated by the main olfactory epithelium and the vomeronasal organ, with pheromones activating the VNO to trigger innate reproductive and social behaviors and neuroendocrine responses. Screening cDNA libraries from rat VNO neurons uncovered a novel family of about 30 seven‑transmembrane domain receptor genes, each expressed in a small subset of VNO neurons and likely encoding mammalian pheromone receptors.

Abstract

In mammals, olfactory sensory perception is mediated by two anatomically and functionally distinct sensory organs: the main olfactory epithelium (MOE) and the vomeronasal organ (VNO). Pheromones activate the VNO and elicit a characteristic array of innate reproductive and social behaviors, along with dramatic neuroendocrine responses. Differential screening of cDNA libraries constructed from single sensory neurons from the rat VNO has led to the isolation of a family of about 30 putative receptor genes. Sequence analysis indicates that these genes comprise a novel family of seven transmembrane domain proteins unrelated to the receptors expressed in the MOE. Moreover, the expression of each member of the gene family is restricted to a small subpopulation of VNO neurons. These genes are likely to encode mammalian pheromone receptors.