Comparative Myocardial Depression of Sevoflurane, Isoflurane, and Halothane in Cultured Neonatal Rat Ventricular Myocytes

Abstract

Sevoflurane, isoflurane, and halothane have a direct cardiodepressant effect on cardiac excitation-contraction coupling in the immature heart, which is mediated by an interaction with the L-type Ca2+ channel.