Peptic ulcers induced by piroxicam.

Abstract

Peptic ulcers induced by piroxicamPiroxicam is a commonly used non-steroidal anti-inflammatory drug.Its advantages include its high efficacy, its long plasma half life (mean of 38 hours), which enables it to be taken as a single daily dose, and its supposedly low incidence of gastrointestinal side effects.We report, however, on four patients with peptic ulcers induced by piroxicam seen over four months.None had had dyspeptic symptoms previously, and none was taking other ulcerogenic drugs. Case reportsCase 1-A 79 year old housewife with a 40 year history of arthritis received phenylbutazone for five years before her treatment was changed to piroxicam 20 mg daily in September 1983.In November she developed anaemia and