Diastereoselective Reactions of Sulfoximines

Abstract

Abstract This review will deal exclusively with the diastereoselective reactions of chiral sulfoximine reagents that lead to the formation of new chiral C-C, C-N, and C-O bonds. The diastereoselective reactions of lithiated sulfoximines with electrophiles, including carbonyl compounds, imines, Michael acceptors and alkyl halides are discussed. The diastereoselective conjugate addition reactions of vinyl sulfoximines with various carbon, nitrogen and oxygen nucleophiles are also addressed. A number of studies reported here were performed on racemic substrates but only one enantiomer has been shown to assist the reader.