Odor structure-activity relationships compared in human and nonhuman primates.

Abstract

The ability of 4 squirrel monkeys to distinguish between members of 3 homologous series of substances (aliphatic alcohols, aldehydes, and ketones) was investigated, and their performance was compared with that of a group of 10 human participants. With all 3 substance classes, and in both species, a significant negative correlation was found between discrimination performance and structural similarity of odorants in terms of differences in carbon chain length. These findings suggest carbon chain length of aliphatic odorants to be one of presumably several determinants of the interaction between stimulus molecule and olfactory receptor and support the assumption that human and nonhuman primates may share common mechanisms of odor quality perception.