Reduction of size of thyroid with radioactive iodine in multinodular non-toxic goitre.

Abstract

prednisolone followed by a reducing course of oral prednisolone.She improved clinically and her erythro- cyte sedimentation rate settled to 19 mm in the first hour after 10 days.The tracheostomy tube was removed after 12 days and good movement was seen in both vocal cords.Her recovery was further compli- cated by an extensive left deep venous thrombosis requiring anticoagulation.Antinuclear factor titres rose to >1/10 240 for both IgG and IgM.No anti-DNA binding was detected.C3 and C4 concentrations were normal.No lupus anti- coagulant was detected.There was no evidence of renal impairment, though 24 hour urinary protein excretion was 0-56 g (normal <0 150 g).Nine months after discharge she was well, her blood pressure being controlled with verapamil 120 mg twice daily.Antinuclear factor titres had fallen to 1/1280 and all other values had returned to normal.O i 12 Time (months) Mean (SEM) thyroid volume after treatment with iodine-131 in 20 patients with multinodular non-toxic goitre remaining euthyroid during follow up