Psychophysiology · 1997 · 209 citations · 9 references
NursingPharmacologyPharmacotherapyPsychopharmacologyPsychophysiologySleep MedicineSleep AssessmentSleep DisturbanceSleep HealthSleep ManagementSleep PhysiologySleep PsychophysiologyCountermeasures Against SleepinessDrowsiness EffectsElectroencephalography-based Sleep AnalysisNonpharmacological Sleep ManagementObjective Sleepiness TestingSleepSleepiness MeasurementWake-promoting Therapies
Previous research has shown that caffeine and a < 15-min nap effectively and separately reduce sleepiness in drivers for 1 hr. In the present study, we examined in 12 sleepy individuals the treatments combined, taken during a 30-min break, prior to a longer (2 hr) continuous monotonous afternoon drive in a car simulator. Nonnap comparisons were 200 mg caffeine only and placebo. For placebo, driving incidents, subjective and electroencephalographic measures of sleepiness all reflected a mid-afternoon peak. This peak was significantly reduced by caffeine and eliminated by the combined treatment, which reduced incidents to 9% of placebo levels versus 34% of placebo levels for caffeine alone. Naps comprising "nonsleep dozing" were still effective.
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Sleep related vehicle accidents
James A. Horne, L A Reyner · BMJ · 1995 · 904 citations
Caffeine disposition after oral doses
Maurizio Bonati, Roberto Latini, Ferruccio Galletti et al. · Clinical Pharmacology & Therapeutics · 1982 · 355 citations