Development of a NIR-based blend uniformity method for a drug product containing multiple structurally similar actives by using the quality by design principles

Real-time monitoring of drug concentration in a continuous powder mixing process using NIR spectroscopy

Aditya U. Vanarase, Manel Alcalà, Jackeline I. Jérez Rozo et al. · Chemical Engineering Science · 2010 · 202 citations

Pharmacy, Pharmaceutical Analysis, Pharmaceutics +9

Quality-by-Design (QbD): An integrated multivariate approach for the component quantification in powder blends☆

Huiquan Wu, Mobin A. Tawakkul, Maury White et al. · International Journal of Pharmaceutics · 2009 · 92 citations

Natural Sciences, Materials Engineering, Materials Science +11

A Process Analytical Technology approach to near-infrared process control of pharmaceutical powder blending. Part I: D-optimal design for characterization of powder mixing and preliminary spectral data evaluation

Arwa S. El‐Hagrasy, Frank d'Amico, James K. Drennen · Journal of Pharmaceutical Sciences · 2005 · 89 citations

Natural Sciences, Chemistry, Pharmaceutics +17

Real-time on-line blend uniformity monitoring using near-infrared reflectance spectrometry: A noninvasive off-line calibration approach

Yusuf Sulub, Busolo Wabuyele, Paul Gargiulo et al. · Journal of Pharmaceutical and Biomedical Analysis · 2008 · 77 citations

Natural Sciences, Chemistry, Food Science +16

In-line quantification of drug and excipients in cohesive powder blends by near infrared spectroscopy

Celine Valeria Liew, Atul D. Karande, Paul Wan Sia Heng · International Journal of Pharmaceutics · 2009 · 74 citations

Pharmacy, Pharmaceutical Analysis, Pharmaceutics +16