A novel antagonist of CRTH2 blocks eosinophil release from bone marrow, chemotaxis and respiratory burst

Abstract

These data further emphasize the importance of CRTH2 in eosinophil function and show that Cay10471 is a highly potent and selective antagonist of PGD(2)-induced eosinophil responses. Cay10471 might hence be a useful compound for the treatment of allergic diseases.