Ochrindoles A-D: New Bis-Indolyl Benzenoids from the Sclerotia of Aspergillus ochraceus NRRL 3519

Abstract

Four new prenylated bis-indolyl benzenoid metabolites (ochrindoles A-D; 1-4) were isolated from antiinsectan organic extracts of the sclerotia of Aspergillus ochraceus (NRRL 3519). The structures of these compounds were determined primarily through HMBC, selective INEPT, and NOESY experiments. These compounds displayed moderate activity in feeding assays against the corn earworm Helicoverpa zea and the driedfruit beetle Carpophilus hemipterus. Compounds 1-4 also exhibited activity against Gram-positive bacteria.