Cascade Reactions in Quantitative Solid-State Syntheses

Abstract

100 % yield in the absence of the liquid phase: A one-pot synthesis of highly substituted pyrroles, which proceeds in solution with moderate yields, functions quantitatively in the solid-solid variant, and that at much lower temperatures, although at least four reaction steps are required. The reaction execution in the absence of liquid phases avoids product workup because of the 100 % yield and is thus resource-saving and environmentally friendly.