Preoperative Small-Dose Ketamine Has No Preemptive Analgesic Effect in Patients Undergoing Total Mastectomy

Abstract

We administered the same small dose of ketamine before or after surgery. The preoperative administration of 0.15 mg/kg ketamine in patients undergoing total mastectomy did not elicit a preemptive analgesic effect. Ketamine given at closure reduced the patient-controlled analgesia morphine requirement in the first 2 h after surgery.