Clinical and Applied Thrombosis/Hemostasis · 2007 · 17 citations · 37 references
MedicineHematologyPathologyHemostasisMolecular PathologyUltrasonographyCardiovascular DiseaseEndothelial DysfunctionHemostasis DisordersThrombosisThrombotic DisordersVon Willebrand DiseaseAbdominal Aorta UltrasoundAtherosclerosis RiskAtherosclerotic Plaque CharacterizationAtherosclerotic Risk AssessmentAtherosclerotic Risk ReductionCarotid Plaque MorphologyCommon Carotid ArteryHereditary Bleeding Disorders
OBJECTIVE: To verify whether a hereditary bleeding tendency, such as von Willebrand disease (vWD) type IIB, protects against the onset of atherosclerosis. PARTICIPANTS AND METHODS: Twenty-four patients with vWD type IIB and 24 healthy controls, matched for common atherosclerotic risk factors. All patients were evaluated by color Doppler ultrasound of the common carotid, carotid bifurcation, common femoral artery, brachial artery, and abdominal aorta, investigating intima-media thickness (IMT) and presence of plaques in each arterial district. Flow mediated dilation (FMD) of the brachial artery was used to test endothelial function. RESULTS: vWD type IIB patients presented no significant difference in IMT in any arterial district. FMD showed no differences between the 2 groups. CONCLUSIONS: The quantitative clotting defect characteristic of vWD type IIB does not seem to protect against atherosclerosis.
37
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
Stefanie Dimmeler, Ingrid Fleming, Beate Fißlthaler et al. · Nature · 1999 · 3.6K citations
Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging.
P Pignoli, Elena Tremoli, Andrea Poli et al. · Circulation · 1986 · 2.4K citations