Efficient Synthesis of α-Galactosyl Ceramide Analogues Using Glycosyl Iodide Donors

Abstract

The combination of reactive galactosyl iodide donors with electron-rich acceptor lipids provides highly stereoselective and efficient routes to alpha GalCer analogues. Using per-O-silylated donors, key intermediates can be obtained in a three-step, one-pot sequence providing useful constructs for analogue development.