Chemical Communications · 2012 · 51 citations · 39 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistryCatalyst DesignCatalyst PreparationCatalyst SynthesisCatalytic MechanismsHeterocycle SynthesisOrganic SynthesisHeck ReactionQuinoline Synthesis
A novel catalytic method for synthesizing 4-aryl-2-quinolinones is reported. The process involves two mechanistically independent, sequential Pd(II)-catalyzed reactions--the oxidative Heck reaction and the intramolecular C-H amidation--both of which smoothly proceed in the presence of a single catalytic system in a one-pot manner.
39