Skeletal Muscle Insulin Resistance in Morbid Obesity: The Role of Interleukin-6 and Leptin

Abstract

In morbid obesity: (1) Subcutaneous adipose tissue releases interleukin-6 which could then mediate insulin resistance in skeletal muscle. (2) Although there is increased secretion of leptin by the subcutaneous adipose tissue, leptin levels are not correlated to the sensitivity of glucose metabolism to insulin in muscle.