The Journal of Clinical Endocrinology & Metabolism · 1966 · 34 citations · 0 references
MedicineEndocrinologyInternal MedicineMineral MetabolismRenal PathologyRenal PathophysiologyDiabetes MellitusMetabolic EvaluationRenal AssessmentRenal DiseaseRenal Function TestsRenal Tubular DisordersDiabetes Insipidus SyndromesDifferential Diagnosis CriteriaDifferential Symptom DiagnosisRenal DisordersRenal Tubular DysfunctionSerum Osmolality AssessmentUrine OsmolalityWater Deprivation Test
A simple, safe and standardized overnight 8-hr water deprivation test is described for differentiating diabetes insipidus, due to either antidiuretic hormone(ADH) lack or renal tubular disease, from psychogenie polydipsia by means of the measurement of serum and urine osmolalities. The diagnosis in the patients was first made by performing a standard intravenous hyper tonic sodium chloride infusion test and measuring its effect on urine flow. No overlap in either urine or serum osmolalities was apparent between normals and those with organic diabetes insipidus in the subjects examined in this series.