Journal of Surgical Oncology · 1991 · 21 citations · 21 references
MedicineOncologyRadiation OncologyChemotherapyClinical Radiation OncologyDysphagiaEsophageal CancerExternal Beam RadiotherapyGastrointestinal Cancer RadiotherapyRadiation TherapyComplete Response AssessmentEsophageal Cancer PalliationEsophageal Cancer-related DysphagiaExternal Beam Radiation CareGastroesophageal Junction Cancer RadiotherapyMedian AgePilot Randomized Controlled TrialsPilot Study Design
Fifty patients with carcinoma of the esophagus were entered in a randomized pilot study to test the efficacy of intraluminal radiotherapy (ILRT) and concurrent 5-fluorouracil (5-FU) infusion. The median age was 65 years, with 80% having middle third lesions; in 62%, the lesions were longer than 5 cm. After external beam therapy of 50 Gy in 5 weeks, patients were randomized to receive chemotherapy. Significant improvement in dysphagia was recorded in 76% patients with complete response in 47 cases ranging from 6 to 27 months. The overall survival at 2 years was 15% with ILRT alone versus 22% with ILRT plus 5-FU infusion.
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Results of radical radiotherapy of squamous cell carcinoma of the oesophagus
G.A. Newaishy, G. Read, W. Duncan et al. · Clinical Radiology · 1982 · 143 citations