Journal of Medicinal Chemistry · 1980 · 24 citations · 0 references
PharmacyMedicinal ChemistryPharmacologyOrganic ChemistryStructure-activity RelationshipsSynthetic Medicinal ChemistryCardiovascular PharmacologyHeterocycle SynthesisHypertension ManagementHypertension PharmacotherapyOrganic SynthesisSteroid PharmacologyAntihypertensive Drug TherapyAntihypertensive PharmacologyAntihypertensive TreatmentMedicinal Heterocycles
The synthesis of a series of 5,6-diarylpyridazinones is described. Some members of this series display an antihypertensive effect in both the spontaneously hypertensive rat (SHR) model and the deoxycorticosteroid (DOCA) model of hypertension. The most potent compounds in the series have halogen substituents on the 5,6-diphenyl rings, a beta-substituted alkyl group at the 2 position of the ring, and acetyl or cyano substituent at the 4 position.