Concepedia

Quantitative assessment of P-glycoprotein function in the rat blood–brain barrier by distribution volume of [11C]verapamil measured with PET

Joost Bart, Antoon T. M. Willemsen, Harry J.M. Groen, Winette T.A. van der Graaf, Theodora D Wegman, Willem Vaalburg, Elisabeth G.E. de Vries, N. Harry Hendrikse

NeuroImage · 2003 · 80 citations · 27 references

DOI

Concepts

References

27

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

F Thiébaut, T Tsuruo, Hironobu Hamada et al. · Proceedings of the National Academy of Sciences · 1987 · 2.8K citations · Full text

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Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Carlos Cordon‐Cardo, James P. O’Brien, D Casals et al. · Proceedings of the National Academy of Sciences · 1989 · 1.7K citations · Full text

, , +16

Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [ <i>N</i> - <sup>11</sup> C-Methyl]-(−)-Cocaine PET Studies in Human Subjects

Jean Logan, Joanna S. Fowler, Nora D. Volkow et al. · Journal of Cerebral Blood Flow & Metabolism · 1990 · 1.5K citations

, , +16

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Alfred H. Schinkel, Els Wagenaar, Carla A.A.M. Mol et al. · Journal of Clinical Investigation · 1996 · 1.3K citations · Full text

, , +15

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

Richard B. Kim, Martin F. Fromm, Christoph Wandel et al. · Journal of Clinical Investigation · 1998 · 1.1K citations · Full text

, , +17