Inhibition of Spontaneous Contractile Activity in Isolated Human Detrusor Muscle Strips by Vasoactive Intestinal Polypeptide

Abstract

In a study of 75 isolated human detrusor muscle strips, spontaneous contractions and an associated sustained rise in basal tension were observed in 43 (57%). Vasoactive intestinal polypeptide (VIP) caused significant reductions in the frequency and amplitude of spontaneous contractions and a fall in basal tension. The results suggest that VIP may have a role as an inhibitor of spontaneous activity in the human detrusor.

References

Vasoactive Intestinal Polypeptide in the Normal and Unstable Bladder

Jiang Gu, J. M. Restorick, M.A. Blank et al. · British Journal of Urology · 1983 · 97 citations

Effects of Prostaglandins on the Isolated Human Bladder and Urethra

Karin Andersson, Åsa Ek, C. G. A. Persson · Acta Physiologica Scandinavica · 1977 · 95 citations

Pge 2, Molecular Pharmacology, Urological Research +11

Distribution and motor effect of VIP in female genital tract

Bent Ottesen, J.‐J. Larsen, Jan Fahrenkrug et al. · American Journal of Physiology-Endocrinology and Metabolism · 1981 · 75 citations

Gynecology, Female Reproductive System, Peripheral Nervous System +22

Human female bladder and its noncholinergic contractile function

Wendy Cowan, E.E. Daniel · Canadian Journal of Physiology and Pharmacology · 1983 · 58 citations

Field Stimulation, Peripheral Nervous System, Neuromuscular Blockade +19

Effect of detrusor muscle length and tension on its response to pharmacologic and electrical stimulation Part II. In vitro study

Alex E. Finkbeiner, Nabil K. Bissada · Urology · 1980 · 11 citations

Mechanobiology, Stimulation Device, Muscle Function +10