Concepedia

Novel Method for the Preparation of Enantiomerically Pure Propargylic Substituted Compounds

Yoshiaki Nishibayashi, H. Imajima, Gen Onodera, Sakae Uemura

Organometallics · 2005 · 30 citations · 32 references

DOI

Concepts

Abstract

We have found a novel method for the preparation of enantiomerically pure propargylic alkylated compounds from an achiral propargylic alcohol assisted by a ruthenium complex bearing BINAP as a chiral ligand. It is noteworthy that products bearing completely opposite configurations are obtained with an almost 100% ee.

References

32

Asymmetric Catalysis: Science and Opportunities (Nobel Lecture) Copyright© The Nobel Foundation 2002. We thank the Nobel Foundation, Stockholm, for permission to print this lecture.

Ryōji Noyori · Angewandte Chemie International Edition · 2002 · 2K citations

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Asymmetric Catalysis: Science and Opportunities (Nobel Lecture 2001)

Ryōji Noyori · Advanced Synthesis & Catalysis · 2003 · 1.9K citations

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Dramatic Improvement of the Enantiomeric Excess in the Asymmetric Conjugate Addition Reaction Using New Experimental Conditions

A. Alexakis, Cyril Benhaïm, Stéphane Rosset et al. · Journal of the American Chemical Society · 2002 · 276 citations

Novel Propargylic Substitution Reactions Catalyzed by Thiolate-Bridged Diruthenium Complexes via Allenylidene Intermediates

Yoshiaki Nishibayashi, Issei Wakiji, Masanobu Hidai · Journal of the American Chemical Society · 2000 · 219 citations

, , +10

Ruthenium‐Catalyzed Propargylic Substitution Reactions of Propargylic Alcohols with Oxygen‐, Nitrogen‐, and Phosphorus‐Centered Nucleophiles

Yoshiaki Nishibayashi, Marilyn Daisy Milton, Youichi Inada et al. · Chemistry - A European Journal · 2005 · 184 citations

, , +13