Chemiluminescence of Potassium Permanganate–Glyoxal–Sulfur Contained Compound System

Abstract

Abstract Sulfur contained compound (SCC) had different abilities in term of increasing the intensity of chemiluminescence of potassium permanganate with glyoxal. In a flow system, including methimazole, captopril, cimetidine, methionine, chloropromazine hydrochloride, chlorprothixene and propacil, enhanced intensity was detected, therefore the CL of potassium permanganate–glyoxal–SCC system was studied. Under the optimized experimental conditions, low detection limit and large calibration ranges for Sulfur contained compound were obtained. The proposed method allowed 90 injections h−1 with excellent repeatability and precision. The method was successfully applied to the determination of six SCC in commercial pharmaceutical formulations with recoveries in the range of 97.24–102.2%. The method was validated through the pharmacopoeia reference method. The possible chemiluminescence reaction mechanism of potassium permanganate–glyoxal–SCC was discussed briefly.