Synthesis of Oligoribonucleotides by the H-Phosphonate Approach Using Base Labile 2′-O-Protecting Groups. V. Recent Progress in Development of the Method

Abstract

Abstract A simple and inexpensive method for the preparation of oligoribonucleotides using N-isopropoxyacety(phenoxyacetyl)-2′-O-(2-chlorobenzoyl)-5′-O-dimethoxytritylnucleoside H-phosphonate building blocks has been developed.