Auto‐Tandem Catalysis: Synthesis of Substituted 11<i>H</i>‐Indolo[3,2‐<i>c</i>]quinolines <i>via</i> Palladium‐Catalyzed Intermolecular CN and Intramolecular CC Bond Formation

Abstract

Abstract D ‐Ring substituted 11 H ‐indolo[3,2‐ c ]quinolines ( 4 ) have been prepared via auto‐tandem consecutive intermolecular Buchwald‐Hartwig reaction and intramolecular palladium‐catalyzed arylation on 4‐chloroquinoline ( 1 ) with N ‐unsubstituted 2‐chloroanilines ( 2 ). The reported 11 H ‐indolo[3,2‐ c ]quinolines ( 4 ) represent the first examples in which tandem catalysis has been used to construct N ‐unsubstituted carbolines.