Effects of Increased Intra-abdominal Pressure upon Intracranial and Cerebral Perfusion Pressure before and after Volume Expansion

Abstract

Elevated IAP increases ICP and decreases CPP and cardiac index. Volume expansion further increases ICP yet improves CPP via its greater positive effect upon mean arterial pressure (*p < 0.05, analysis of variance. All measurements are mean +/- SEM in mm Hg).