Journal of Natural Products · 2000 · 110 citations · 4 references
Life SciencesMicrobiologyPlant PathologyChromatographic AnalysisDrug DiscoveryMycologyAntifungal AgentsFungal PathogenesisFungal Secondary MetabolitesNatural Product Drug DiscoveryBioassay DevelopmentBioassay ValidationFungal Drug DiscoveryNatural Antifungal CompoundsNew Antifungal AgentsNovel Antifungal Drug Development
A new bioassay has been developed combining the simplicity of direct bioautography with the improved chromatographic resolution of 2D-TLC. Mixtures of structurally diverse antifungal agents were tested to establish the validity and utility of this method in the discovery of new natural products with activity against agriculturally important fungal pathogens.
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