Controlled Trial of Platelet Anti-Aggregating Agents and Subcutaneous Heparin in Prevention of Postoperative Deep Vein Thrombosis in High Risk Patients

Abstract

In a prospective randomised trial, three groups of 20 patients each were compared. A first group served as a control, a second group received dipyridamole and acetylsalicylic acid and a third group received low doses of heparin. The incidence of deep vein thrombosis determined by the 125I-fibrinogen test was 40% in the first group, 50% in the second group, and 5% in the third group. The differences between the heparin group and the two other groups are statistically significant. No wound complication and no haematoma at the injection site occurred.