Rhabdomyosarcoma of head and neck in children

Abstract

Combined systematic therapy offers the best chance of cure for children with rhabdomyosarcoma originating in the head and neck. Recommended therapy includes: 1. local excision or biopsy; 2. radiation therapy with doses of 6,000 rads/6 weeks, and 3. multi-drug chemotherapy, i.e., vincristine sulfate, actinomycin D, and cyclophosphamide. Severe ocular, dental, soft tissue, and possibly bone complications may be encountered. Provision for prompt medical and nursing support must be available for possible associated morbidity. Of 19 patients treated, minimum 2-year survival is 74%, and local control 89%. Late recurrences or complications require further follow-up.