The Nephron journals/Nephron journals · 2008 · 50 citations · 0 references
MedicinePharmacologyPhysiologyExcretionMineral MetabolismRenal PathophysiologyElectrolyte HomeostasisRenal ExcretionRenal PhysiologySodium HomeostasisUrinary ExcretionRenal Pressure-natriuresisSalt LoadingSalt-sensitive Blood Pressure RegulationSalt-sensitive HypertensionTubular Sodium ReabsorptionUrinary Sodium ExcretionUrine Electrolytes
A substance was isolated from the urines of normotensive and hypertensive subjects undergoing salt load experiments. This substance was tested in rats for its natriuretic properties. It was found that both groups excrete a natriuretic material. The natriuretic activity of the material isolated from hypertensive subjects, who responded to the salt loading procedure with an exaggerated natriuresis, was significantly higher than that deriving from normotensive subjects.