Natriuretic Activity of a Substance Isolated from Human Urine During the Excretion of a Salt Load

Abstract

A substance was isolated from the urines of normotensive and hypertensive subjects undergoing salt load experiments. This substance was tested in rats for its natriuretic properties. It was found that both groups excrete a natriuretic material. The natriuretic activity of the material isolated from hypertensive subjects, who responded to the salt loading procedure with an exaggerated natriuresis, was significantly higher than that deriving from normotensive subjects.