Clinical and Experimental Pharmacology and Physiology · 1990 · 18 citations · 18 references
MedicineEndocrinologyPharmacologyNeuropharmacologyPharmacodynamicsSteroid BiochemistryAdrenal Steroid HormonesCholinergic PharmacologyCorticosteroid TherapySteroid Hormone BiochemistrySteroid Hormone SignalingSteroid PharmacologyCorticosteroid PhysiologyGlucocorticoid PharmacologyGlucocorticoid Receptor SensitivityGlucocorticoid ReceptorsGlucocorticoid SensitivityMuscarinic Receptor PharmacologyMuscarinic Receptor SubtypesSteroid Hormone Pharmacology
1. The effects of corticosteroid pretreatment on acetylcholine (ACH)-induced contraction of bronchial smooth muscle (BSM) were studied. 2. ACH dose-response curves for dexamethasone (DM)- and corticosterone (B)-treated but not deoxycorticosterone (DOC)-treated BSM were significantly shifted to the right; this provides evidence that glucocorticoid treatment reduced the sensitivity of BSM to ACH. 3. Morphine enhanced BSM contraction in response to ACH by 20%. DM suppressed this enhancement. 4. These findings correlated well with the reduction of muscarinic receptor numbers in BSM by glucocorticoids in our previous study. In addition, glucocorticoids reduced the sensitivity of BSM to opioids.
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Foot-shock induced stress increases β-endorphin levels in blood but not brain
Jean Rossier, Edward D. French, Catherine Rivier et al. · Nature · 1977 · 577 citations
Effect of corticosteroids on airway hyperresponsiveness.
Peter J. Barnes · PubMed · 1990 · 143 citations
Pharmacy, Immunology, Pharmacology +17