PharmacyEmergency MedicinePharmacotherapyCardiovascular PharmacotherapyClinical PharmacologyParenteral Drug DeliveryBlood Pressure ManagementHypertension ManagementHypertension PharmacotherapyAntihypertensive Drug TherapyAntihypertensive Infusion TherapyAntihypertensive TreatmentBlood PressureHypertensive Emergency ManagementHypertensive Urgency ManagementNitroprusside TherapyParenteral Drug Administration
The availability of potent antihypertensive drugs that will decrease markedly elevated blood pressure within minutes to hours has changed the concepts of definition and therapy of hypertensive emergencies and urgencies. Intravenous infusion of sodium nitroprusside can be used in the truly emergent situation and is effective, reliable, and safe. While oral therapy is more convenient, it is not as consistently effective as parenteral administration and can lead to excessive reductions in blood pressure that are more difficult to manage than when short-acting agents are given intravenously.
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Autoregulation of Brain Circulation in Severe Arterial Hypertension
Svend Strandgaard, Jes Olesen, E Skinhöj et al. · BMJ · 1973 · 879 citations · Full text
Medicine, Neuroscience, Physiology +17
A Controlled Trial of Nimodipine in Acute Ischemic Stroke
H. J. Gelmers, K. J. Gorter, C. J. de Weerdt et al. · New England Journal of Medicine · 1988 · 426 citations
Treatment of Hypertensive Crisis
Jane F. Desforges, Jane F. Desforges, David A. Calhoun et al. · New England Journal of Medicine · 1990 · 239 citations