Membrane effects of the antitumor drugs doxorubicin and thaliblastine: comparison to multidrug resistance modulators verapamil and trans-flupentixol

The Anticancer Agent Adriamycin Can Be Actively Cytotoxic Without Entering Cells

Thomas R. Triton, Gene K. Yee · Science · 1982 · 572 citations

Medicine, Oncology, Pharmacology +8

Evidence of a specific complex between adriamycin and negatively-charged phospholipids

Erik Goormaghtigh, Pierre Chatelain, J. Caspers et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1980 · 312 citations

Natural Sciences, Biochemistry, Biophysics +13

Three-dimensional Structures of the Mammalian Multidrug Resistance P-glycoprotein Demonstrate Major Conformational Changes in the Transmembrane Domains upon Nucleotide Binding

Mark F. Rosenberg, Alhaji Bukar Kamis, Richard Callaghan et al. · Journal of Biological Chemistry · 2003 · 191 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Comparison of the interaction of doxorubicin, daunorubicin, idarubicin and idarubicinol with large unilamellar vesicles

Laurence Gallois, Marina Fiallo, Arlette Garnier‐Suillerot · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1998 · 145 citations

Life Sciences, Biochemistry, Pharmacology +9

Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines.

James M. Ford, Edward Bruggemann, Ira Pastan et al. · PubMed · 1990 · 123 citations

Medicine, Medicinal Chemistry, Pharmacology +8