Organic Letters · 2004 · 79 citations · 9 references
Natural SciencesChemistryCatalysisOrganic ChemistryCatalytic MechanismsCross-coupling ReactionsHeterocyclic ChemistryAmino AcidsChiral Catalyst DesignCyclopropanation ReactionsEnantioselective Catalyst DesignHeterocyclic ReactivityLigand-controlled SelectivitySelectivitySelectivity Enhancement
The cyclopropanation of styrene with (silanyloxyvinyl)diazoacetates proceeds with exceptional diastereo- and enantioselectivity in the presence of chiral Rh(II) catalysts. 1,8-Naphthoyl-protected amino acids are the most effective Rh(II) ligands for these transformations. [reaction--see text]
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