Calcium Pantothenate. Part 3. Process for the Biologically Active Enantiomer of the Same via Selective Crystallization and Racemization

Abstract

Optically pure calcium (R)-pantothenate has been obtained from the racemic compound via direct fractional crystallization of the single enantiomer. Efficient racemization of the biologically inactive calcium (S)-pantothenate without its decomposition to pantolactone has been developed, resulting in a simple, complete, and efficient technology. The results elaborated in the laboratory have been then successfully applied in the industrial scale process.