Noduliprevenone: A Novel Heterodimeric Chromanone with Cancer Chemopreventive Potential

Abstract

Impressive architecture, important activity! Noduliprevenone (shown here) is a unique marine fungal polyketide, incorporating two unusual chromanone subunits. The absolute configuration was assigned by using a combination of CD spectroscopy, NOE interactions and Mosher's method. Noduliprevenone was found to be an inhibitor of P450 (CYP1 A), and concomitantly induces NAD(P)H:quinone reductase (QR). This modulation of xenobiotic metabolism suggests noduliprevenone to be a cancer chemopreventive agent. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.