Ethanol Increases the Neurotoxic Effect of Tumor Necrosis Factor‐<i>α</i> in Cultured Rat Astrocytes

Abstract

These studies suggest that ethanol increases the susceptibility of astrocytes to TNFalpha-induced cell death by shifting the balance of sphingolipid metabolism in favor of a pathway that increases the susceptibility of astrocytes to the cytotoxic effect of TNFalpha.