Concepedia

Base‐Catalyzed NN Bond Cleavage of Hydrazones: Synthesis of α‐Amino Ketones

Haitao Tang, Yunbing Zhou, Yu Zhu, Hong‐Chao Sun, Min Lin, Zhuang‐Ping Zhan

Chemistry - An Asian Journal · 2014 · 17 citations · 41 references

DOI

Abstract

An efficient Cs2CO3-promoted synthesis of α-amino ketones using hydrazines, aldehydes, and α-haloketones as starting materials through a cascade condensation/nucleophilic substitution/N-N bond cleavage route is developed. The carbonyl group plays a key role in this novel N-N bond cleavage process.

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