A Practical and Green Approach towards Synthesis of Dihydropyrimidinones without Any Solvent or Catalyst

Abstract

A simple, efficient, green, and cost-effective procedure has been developed for the synthesis of dihydropyrimidinones by a solvent-free and catalyst-free Biginelli's condensation of 1,3-dicarbonyl compound, aldehyde, and urea. This approach of direct reaction in neat without solvent and catalyst shows a new direction in green synthesis.