Concepedia

Highly diastereo- and enantioselective copper-catalyzed propargylic alkylation of acyclic ketone enamines for the construction of two vicinal stereocenters

De-Yang Zhang, Fu‐Lin Zhu, Yahui Wang, Xin‐Hu Hu

Chemical Communications · 2014 · 54 citations · 49 references

DOI

Abstract

The first highly diastereo- and enantioselective propargylic alkylation of acyclic ketone enamines to form vicinal tertiary stereocenters has been reported by employing copper catalysis in combination with a bulky and structurally rigid tridentate ketimine P,N,N-ligand.

References

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, , +16

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, , +10

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