Augmentation of Therapeutic Efficacy in Drug-Resistant Tumor Models Using Ceramide Coadministration in Temporal-Controlled Polymer-Blend Nanoparticle Delivery Systems

The therapeutic potential of modulating the ceramide/sphingomyelin pathway

Richard Kolesnick · Journal of Clinical Investigation · 2002 · 347 citations

Life Sciences, Biochemistry, Cell Biology +17

Accumulation of Glucosylceramides in Multidrug-resistant Cancer Cells

Yaakov Lavie, Hui-Ting Cao, Stuart L. Bursten et al. · Journal of Biological Chemistry · 1996 · 342 citations · Full text

Medicine, Oncology, Pharmacology +12

Ceramide glycosylation potentiates cellular multidrug resistance

Yu Liu, Tie-Yan Han, Armando E. Giuliano et al. · The FASEB Journal · 2001 · 303 citations

Medicine, Oncology, Pharmacology +16

pH-Responsive Polymer Microspheres: Rapid Release of Encapsulated Material within the Range of Intracellular pH

David M. Lynn, Mansoor M. Amiji, Róbert Langer · Angewandte Chemie International Edition · 2001 · 256 citations

Pharmacy, Materials Science, Pharmaceutics +14

Poly(Ethylene Oxide)-Modified Poly(β-Amino Ester) Nanoparticles as a pH-Sensitive System for Tumor-Targeted Delivery of Hydrophobic Drugs: Part 2. In Vivo Distribution and Tumor Localization Studies

Dinesh B. Shenoy, Steven R. Little, Róbert Langer et al. · Pharmaceutical Research · 2005 · 245 citations · Full text

Pharmacy, Molecular Pharmaceutics, Pharmaceutics +17