Concepedia

White matter changes in Leber's hereditary optic neuropathy: MRI findings

Wilhelm Küker, Andrew Weir, Gerardine Quaghebeur, Jacqueline Palace

European Journal of Neurology · 2007 · 28 citations · 10 references

DOI

Concepts

Abstract

Leber's hereditary optic neuropathy is a mitochondrial disorder causing bilateral optic nerve degeneration. It is sometimes associated with clinical signs of multiple sclerosis. We report MRI findings in two patients with LHON-MS and comment on possible distinguishing features of this disease entity.

References

10

OCCURRENCE OF A MULTIPLE SCLEROSIS-LIKE ILLNESS IN WOMEN WHO HAVE A LEBER'S HEREDITARY OPTIC NEUROPATHY MITOCHONDRIAL DNA MUTATION

A E Harding, Mary G. Sweeney, David H. Miller et al. · Brain · 1992 · 385 citations

, , +17

Application of the new McDonald criteria to patients with clinically isolated syndromes suggestive of multiple sclerosis

Catherine M. Dalton, Peter Brex, Katherine Miszkiel et al. · Annals of Neurology · 2002 · 291 citations

, , +10

Neuropathology of white matter disease in Leber's hereditary optic neuropathy

Gábor G. Kovács · Brain · 2004 · 110 citations · Full text

, , +17

Magnetic resonance imaging, magnetisation transfer imaging, and diffusion weighted imaging correlates of optic nerve, brain, and cervical cord damage in Leber's hereditary optic neuropathy

Matilde Inglese · Journal of Neurology Neurosurgery & Psychiatry · 2001 · 73 citations · Full text

, , +16

Mitochondrial mutations of Leber's hereditary optic neuropathy: a risk factor for multiple sclerosis

Ludo Vanopdenbosch, B x E n x E dicte Dubois, Marie D’hooghe et al. · Journal of Neurology · 2000 · 68 citations

, , +17