<scp>PEG</scp> matrix enables cell‐mediated local <scp>BMP</scp>‐2 gene delivery and increased bone formation in a porcine critical size defect model of craniofacial bone regeneration

Abstract

The PEG matrix serves as scaffold for cell-mediated BMP-2 gene delivery in guided bone regeneration facilitating cell survival and protein synthesis for at least 4 weeks. Local BMP-2 gene delivery by PEG matrix-embedded cells leads to increased bone formation during critical size defect regeneration.