Folate Receptor-β Imaging Using ^99mTc-Folate to Explore Distribution of Polarized Macrophage Populations in Human Atherosclerotic Plaque

Abstract

Higher numbers of M2-like macrophages were present in areas of high (99m)Tc-folate accumulation than areas with low accumulation. It is anticipated that (99m)Tc-folate imaging using SPECT as a marker for M2-like macrophages in atherosclerosis might be a good indicator for plaque vulnerability.